dMRI typically samples three spatial dimensions and three additional dimensions called “ q-space,” measuring signals that reflect the water diffusion process at a spatial location, along a given direction, with a specified sensitivity. As the technology underlying dMRI has rapidly advanced, it has become the primary technique for non-invasive studies of white matter organization in humans. Water diffusion is hindered and restricted in the presence of these myelinated axons, allowing axonal organization to be characterized using diffusion-weighted MRI (dMRI). The computations in the human brain that give rise to cognition and behavior rely in part on spatially distributed regions that are connected via myelinated axons.
Taken together, these features facilitate easy implementation of best practices for processing of diffusion images while simultaneously ensuring reproducibility. Throughout, QSIPrep provides both visual and quantitative measures of data quality as well as “glass-box” methods reporting.
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Drawing upon a diverse set of software suites to capitalize upon their complementary strengths, QSIPrep automatically applies best practices for dMRI preprocessing, including denoising, distortion correction, head motion correction, coregistration, and spatial normalization. Here we introduce QSIPrep, an integrative software platform for the processing of diffusion images that is compatible with nearly all dMRI sampling schemes. Reproducible research and comparisons across dMRI methods are hindered by incompatible software, diverse file formats, and inconsistent naming conventions. Numerous software platforms have been developed for processing dMRI data, but most work on only a subset of sampling schemes or implement only parts of the processing workflow. While many dMRI acquisition sequences have been developed, they all sample q-space in order to characterize water diffusion. His work in greater Seattle includes many of the region’s flagships including the Microsoft campus, the Amazon Spheres, The Allen Institute, and the decade-long transformation of South Lake Union.Diffusion-weighted magnetic resonance imaging (dMRI) has become the primary method for non-invasively studying the organization of white matter in the human brain. An advocate of sustainable design long before it became mainstream, Steve is known throughout the industry as the leader in creative design practices. A thoughtful mediator and a powerful advocate for his clients, Steve bridges the divide that can often exist between clients and regulatory agencies. Overseeing the civil practice, Steve pushes his team of engineers to reach beyond their discipline, to “think like an owner,” and to strive for vision that extends far beyond engineering. Today, that same character affords him unparalleled relationships with the region’s top architects, developers and jurisdictions.
He attended Washington State University on a wrestling scholarship, competing as a D1 athlete while completing a rigorous engineering program. Steve’s tenacity and perseverance, evident in the firm’s fast growth and continued success, took root far before his working years. He is known for his integrity and dedication to clients, and his influence is represented in the design of over 60 million square feet of facilities throughout the Pacific Northwest. His work with architectural structures of all sizes, shapes, and construction materials includes a prolific body of work with public and private clients in all markets served by the firm. As Jim says, “The commitment to comprehensive documents makes projects easier to construct and more economical to build.” He’s developed a workplace where every team member takes seriously their responsibility to “do it right” and is committed to providing value for the design team, the owner, and the contractor. Since his early career, his focus has been working collaboratively and efficiently with design teams to create superior construction drawings.Ĭoughlin Porter Lundeen’s culture has benefited from his outlook, as it’s founded on creative solutions and dedication to high quality design.
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